Refresh Optive MEGA-3 (30 PF vials) - DryEyeShop
Refresh Optive MEGA-3 (30 PF vials) - DryEyeShop

SKU: ALL 95773

Refresh Optive MEGA-3 (30 PF vials)

Rated 4.5 out of 5
Based on 21 reviews
Regular price
$19.57
Sale price
$19.57
Regular price
$21.75
Shipping calculated at checkout.
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Practical Highlights

  • Active ingredients: Carboxymethylcellulose, glycerin, polysorbate 80
  • Also contains castor oil and flaxseed oil
  • Preservative-free
  • Box of 30 0.4mL vials

Rebecca's Thoughts

Refresh Optive MEGA-3 is part of the Refresh Optive "sub-brand".

What they all have in common is their three active ingredients (CMC, glycerin and polysorbate 80).

The additions in the "MEGA-3" version of Optive are trehalose and flaxseed oil. It also contains castor oil, but so does Refresh Optive Advanced. 

So, this is the Refresh brand's main "lipid" offering. It is not super milky-looking like some of the other lipid based drops (e.g. Systane Complete, Retaine MGD Advanced). 

Refresh Optive MEGA-3 has grown to be one of the Refresh brand's most popular drops. I honestly don't know whether that's because it performs better or just very clever marketing. But what matters is, people like it. 

It's a medium viscosity drop, neither very thick nor very thin. While it's been available for years in individual vials, as of March 2026 it is now also available in multi-dose preservative-free bottles.

Updated 3/11/2026

Our most advanced formula – REFRESH OPTIVE® Mega-3.

Preservative-free, low blur formula fortifies and restores the lipid layer. Its unique blend of natural oils helps prevent tear evaporation.

Treats Dry Eye signs and symptoms associated with Meibomian Gland Dysfunction (MGD).

Nourishes all three layers of the tear film damaged by Dry Eye for immediate, long-lasting relief.

This lipid-enhanced lubricant eye drop is clinically proven to treat the signs and symptoms of Dry Eye. Mega-3 does not require shaking prior to use, unlike Retaine® MGD.

REFRESH OPTIVE® Mega-3 Preservative-Free Lubricant Eye Drops come in sterile, single-use vials you can take with you anywhere and are safe to use as often as needed.

It is the only artificial tear that delivers a blend of flaxseed and castor oils to the tear film, in a stable nano-emulsion formula.

Nano-emulsion technology delivers flaxseed and castor oil, fortifying the lipid layer and helping prevent tear evaporation without compromising patient comfort.

Polysorbate 80 keeps the nano-emulsion from separating, providing consistent stability—no shaking required.

CMC, a water-loving polymer, binds to epithelial cellsto maintain moisture on the ocular surface for rapid on-eye comfort and long-lasting relief.

All OPTIVE® formulas include the patented osmoprotectant property that comes from the three compatible solutes—glycerin, l-carnitine and erythritol—all of which deliver added protection to the corneal epithelial cells against hypertonic stress.

MEGA-3 contains a fourth osmoprotectant, trehalose, for an advanced approach to treating Dry Eye symptoms. 

Drug Facts (from manufacturer's site):

Active Ingredients


Carboxymethylcellulose sodium 0.5% (eye lubricant)
Glycerin 1% (eye lubricant)
Polysorbate 80 0.5% (eye lubricant)

Uses

  • For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.
  • May be used as a protectant against further irritation.

Warnings 

For external use only.

  • To avoid contamination, do not touch tip of container to any surface. Do not reuse. Once opened, discard.
  • Do not touch unit-dose tip to eye. 
  • If solution changes color, do not use.

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions

To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

Other Information

  • Use only if single-use container is intact.
  • Use before expiration date marked on container.
  • Store at 59°-86°F (15°-30°C).
  • Store vials in the pouch until use.
  • RETAIN THIS CART FOR FUTURE REFERENCE.

Inactive Ingredients

BORIC ACID; BUTYLATED HYDROXYL TOLUENE; CASTOR OIL; ERYTHRITOL; FLAXSEED OIL; LEVOCARNITINE; PEMULEN TR-2; POLYOXYL 40 STEARATE; PURIFIED WATER; TREHALOSE. MAY CONTAIN SODIUM HYDROXIDE AND/OR HYDROCHLORIC ACID TO ADJUST PH.

average rating 4.5 out of 5
Based on 21 reviews
  • 5 Stars
    16 Reviews
  • 4 Stars
    3 Reviews
  • 3 Stars
    0 Reviews
  • 2 Stars
    0 Reviews
  • 1 Star
    2 Reviews
90% of reviewers would recommend this product to a friend
Effectiveness
Rated 4 out of 5
Ease of Use
Rated 4 out of 5
Value
Rated 4 out of 5
21 Reviews
Reviewed by Mary A. K., from United States
Verified Buyer
I recommend this product
Age Range
61 - 70
Gender
Female
Use scleral lenses or PROSE
No
Eye Condition(s)
  • Evaporative dry eye
Rated 5 out of 5
Review posted

Increased eye comfort

My optometrist recommended these drops, and I was really impressed by how comfortable my RGP lenses were when I used these.

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Effectiveness
Rated 5 out of 5
Ease of Use
Rated 5 out of 5
Value
Rated 4 out of 5
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Reviewed by Maureen T., from United States
Verified Buyer
I recommend this product
Age Range
61 - 70
Gender
Female
Use scleral lenses or PROSE
No
Eye Condition(s)
  • Dry eye disease
  • Nocturnal lagophthamos
Rated 5 out of 5
Review posted

Best treatment for dry eyes!

I’ve been using this product for years and attest to the fact that it really helps to relieve dry eyes. I use this every morning .

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Effectiveness
Rated 5 out of 5
Ease of Use
Rated 5 out of 5
Value
Rated 5 out of 5
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Reviewed by MARYANNE P., from United States
Verified Buyer
I recommend this product
Age Range
61 - 70
Gender
Female
Use scleral lenses or PROSE
Yes
Eye Condition(s)
  • Dry eye disease
  • Other
Rated 5 out of 5
Review posted

REFRESH MEGA3

Really helps my eyes relax, just feels good.

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Effectiveness
Rated 5 out of 5
Ease of Use
Rated 5 out of 5
Value
Rated 4 out of 5
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Reviewed by Sharon Weitz C., from Mexico
Verified Buyer
I recommend this product
Age Range
61 - 70
Gender
Female
Use scleral lenses or PROSE
No
Eye Condition(s)
  • Dry eye disease
Rated 5 out of 5
Review posted

Dry Eye

Prescribed by my doctor Relieves my dryness

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Effectiveness
Rated 5 out of 5
Ease of Use
Rated 5 out of 5
Value
Rated 5 out of 5
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Reviewed by Stephanie, from Canada
Verified Buyer
I recommend this product
Age Range
31 - 40
Gender
Female
Use scleral lenses or PROSE
No
Eye Condition(s)
  • Dry eye disease
  • Blepharitis/MGD
  • Non-closing eyelid(s)
Systemic diseases/conditions related to eye issues
  • Sjogrens/Lupus/Rheumatoid arthritis
Rated 5 out of 5
Review posted

Looove these

Over the last 3ish years I've moved from/through Hylo --> Thealoz duo gel singles --> now to Refresh Optive Mega 3 and each has felt like a big step up. I was using Hylo constantly, with Refresh I'm down to 2-3 times a day. I'm grateful to have found them!

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Effectiveness
Rated 5 out of 5
Ease of Use
Rated 5 out of 5
Value
Rated 4 out of 5
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