Drops, gels and ointments: Ingredients Reference List

Detailed list with active and inactive ingredients, preservatives, and packaging sizes, by brand. 

Notes about this list: 

  • Preservatives are highlighted in PINK (or DARK PINK for BAK).
  • Vasoconstrictors are highlighted in RED (vasoconstrictors have a well documented rebound redness effect and are not appropriate for regular use).
  • Lipids (oils) are highlighted in BLUE
  • The list is mostly products sold as "Lubricant eye drops", however, I have also included "Multi-symptom" type drops because they are often labeled for dry eye but contain ingredients that are harmful for people who have dry eye.

Product

Packaging

Active ingredients

Inactive ingredients (preservative highlighted)

Refresh Classic
(Allergan)
30 PF vials (0.4 mL) Polyvinyl Alcohol 1.4% Povidone 0.6% Purified water, sodium chloride. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Refresh Tears
(Allergan)
15mL bottle Carboxymethylcellulose Sodium Oxychloro complex, Sodium Borate decahydrate, Sodium chloride, Potassium chloride, Calcium chloride dihydrate, Magnesium chloride hexahydrate, Boric acid, Sodium hydroxide to adjust pH and Purified water. 
Refresh Plus
(Allergan)
30 PF vials (0.4 mL) Carboxymethylcellulose sodium 0.5%  Calcium chloride; magnesium chloride; potassium chloride; purified water; sodium chloride; and sodium lactate. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH. 
Refresh Optive
(Allergan)
30 PF vials (0.4 mL) Carboxymethylcellulose sodium 0.5%, Glycerin 0.9% Boric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; purified water; sodium borate decahydrate; and sodium citrate dihydrate.
15mL bottle Boric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; purified water; PURITE® (stabilized oxychloro complex); sodium borate decahydrate; and sodium citrate dihydrate.
Refresh Optive Advanced
(Allergan)
30 PF vials (0.4 mL) Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5% Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide.
10mL bottle Boric acid; castor oil; erythritol; levocarnitine; carbomer copolymer type A; purified water; and PURITE®(stabilized oxychloro complex). May also contain sodium hydroxide to adjust pH.
Refresh Optive MEGA-3
(Allergan)
30 PF vials (0.4 mL) Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5% Boric acid; butylated hydroxyl toluene; castor oil; erythritol; flaxseed oil; levocarnitine; pemulen TR-2; polyoxyl 40 stearate; purified water; sodium hydroxide; trehalose.
Refresh Celluvisc
(Allergan)
30 PF vials (0.4 mL) Carboxymethylcellulose sodium 1% Calcium chloride, potassium chloride, purified water, sodium chloride, and sodium lactate.
Refresh Optive Gel Drops
(Allergan)
10mL bottle Carboxymethylcellulose sodium 10mg in 1mL, glycerin 9mg in 1mL Boric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; PURITE® (stabilized oxychloro complex); sodium borate decahydrate; sodium citrate dihydrate; purified water.
Refresh PM
(Allergan)
3.5g tube Mineral Oil 42.5%White Petrolatum 57.3% Lanolin alcohols
Refresh LacriLube
(Allergan)
3.5g tube Mineral Oil 42.5%White Petrolatum 56.8% Chlorobutanol and lanolin alcohols.
Refresh Liquigel
(Allergan)
15mL bottle Carboxymethylcellulose sodium 1% Boric acid, calcium chloride, magnesium chloride, potassium chloride, purified water, PURITE® (stabilized oxychloro complex), sodium borate, and sodium chloride.
Systane Ultra
(Alcon)
25 PF vials (0.7 mL)
60 PF vials (0.7 mL)
Polyethylene Glycol 400 0.4%, Propylene Glycol 0.3% Aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium chloride, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
10mL bottle Aminomethylpropanol, boric acid, hydroxypropyl guar, POLYQUAD* (polyquaternium-1) 0.001% preservative, potassium chloride, purified water, sodium chloride, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Systane Balance
(Alcon)
10mL bottle Propylene Glycol 0.6% Boric acid, dimyristoyl phosphatidylglycerol, edetate disodium, hydroxypropyl guar, mineral oil, polyoxyl 40 stearate, POLYQUAD® (polyquaternium-1) 0.001% preservative, sorbitan tristearate, sorbitol and purified water. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Systane
(Alcon)
28 PF vials (0.4 mL) Polyethylene Glycol 400 0.4%, Propylene Glycol 0.3% Boric acid, calcium chloride, hydroxypropyl guar, magnesium chloride, potassium chloride, purified water, sodium chloride, zinc chloride. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
15mL bottle Boric acid, calcium chloride, hydroxypropyl guar, magnesium chloride, polyquaternium-1 as a preservative, potassium chloride, purified water, sodium chloride, zinc chloride. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Systane Nighttime ointment
(Alcon)
3.5g tube White petrolatum 94% Mineral oil 3% Anhydrous Liquid Lanolin 3%.
Systane Lubricant Eye Gel
(Alcon)
10g Hypromellose (0.3%) Carbopol 980, phosphonic acid, purified water, sodium perborate and sorbitol. May contain sodium hydroxide to adjust pH.
Systane Gel Drops
(Alcon)
10mL bottle Polyethylene Glycol 400 0.4%, Propylene Glycol 0.3% Aminomethylpropanol, boric acid, edetate disodium, hydroxypropyl guar, POLYQUAD® (polyquaternium-1) 0.001% preservative, potassium chloride, sodium chloride, sorbitol and purified water. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Systane Day & Night
(Alcon)
Two 10mL bottles (Systane Gel Drops and Systane Ultra) See Systane Gel Drops and Systane Ultra See Systane Gel Drops and Systane Ultra
Systane Sport
(Alcon)
Two 10mL bottles Polyethylene Glycol 400 0.4% Lubricant Propylene Glycol 0.3% Aminomethylpropanol, boric acid, hydroxypropyl guar, POLYQUAD® (polyquaternium-1) 0.001% preservative, potassium chloride, purified water, sodium chloride, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Systane Contacts
(Alcon)
12mL bottle dextran, hydroxypropyl methylcellulose sodium chloride, potassium chloride, with edetate disodium 0.1% and POLYQUAD® (polyquaternium-1) 
Genteal Mild
(Alcon)
15mL / 25mL bottle Hypromellose 0.2% Boric acid, calcium chloride dihydrate, GenAqua (sodium perborate), phosphonic acid, potassium chloride, purified water, and sodium chloride
Genteal Moderate
(Alcon)
15mL bottle Dextran 70 0.1%, Glycerin 0.2%, Hypromellose 0.3% Boric acid, calcium chloride, glycine, hydrochloric acid and/or sodium hydroxide (to adjust pH), magnesium chloride, POLYQUAD® (polyquaternium-1) 0.001% preservative, polysorbate 80, potassium chloride, purified water, sodium chloride, zinc chloride.
Genteal Gel (Severe)
(Alcon)
10g tube Hypromellose 0.3%. carbopol 980, phosphoric acid, purifed water, sodium hydroxide, sodium perborate, and sorbitol
Genteal ointment
(Alcon)
3.5g White petrolatum 93% Mineral oil 4% anhydrous liquid lanolin
Genteal Tears
(Alcon)
Previously Tears Naturale Free
36 PF Vials (0.9 mL) Dextran 70 0.1%, Hypromellose 2910 0.3% Potassium Chloride, Purified Water, Sodium Borate, Sodium Chloride, May contain: Hydrochloric Acid, Sodium Hydroxide
Bion Tears
(Alcon)
28 PF vials (0.4 mL) Dextran 70 0.1%, Hypromellose 2910 0.3%  Calcium chloride, magnesium chloride, potassium chloride, purified water, sodium bicarbonate, sodium chloride, zinc chloride, hydrochloric acid and/or sodium hydroxide and/or carbon dioxide to adjust pH.
Soothe XP
(Bausch & Lomb)
15mL bottle Light mineral oil (1.0%), Mineral oil (4.5%) boric acid, edetate disodium, octoxynol-40, polyquaternium-1 (preservative), polysorbate 80, purified water, sodium borate decahydrate. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH).
Soothe Long Lasting Hydration
(Bausch & Lomb)
15mL bottle  Povidone (2.0%) benzalkonium chloride (0.005%), boric acid, edetate disodiumdihydrate, purified water, sodium borate, sodium chloride, tyloxapol. Hydrochloric acid and/or sodium hydroxide may be used to adjust pH.
Soothe Hydration
(Bausch & Lomb)
15mL bottle  Povidone (1.25%) boric acid, potassium chloride, sodium borate and sodium chloride;preserved with edetate disodium 0.1% and sorbic acid 0.1%
Soothe Preservative Free Lubricant
(Bausch & Lomb)
28 PF Vials (0.6 mL) Glycerin (0.6%) Propylene Glycol (0.6%) boric acid, hydroxyalkylphosphonate, purified water, sodium alginate, sodium borate
Soothe Night Time Ointment
(Bausch & Lomb)
3.5g tube Mineral oil (20%), White petrolatum (80%)  none
Advanced eye relief dry eye rejuvenation
(Bausch & Lomb)
15mL bottle Glycerin (0.3%) Propylene glycol (1.0%) benzalkonium chloride (0.01%), boric acid, edetate disodium, potassium chloride, purified water, sodium borate, sodium chloride. Hydrochloric acid and/or sodium hydroxide may be used to adjust pH
Oasis Tears
(Oasis Medical)
30 PF vials (0.3 mL) Glycerin (0.2%) Hyaluronan, sodium chloride, sodium phosphate dibasic, sodium phosphate monobasic, water.
Oasis Tears Plus
(Oasis Medical)
30 PF vials (0.3 mL) Glycerin (0.2%) Hyaluronan, sodium chloride, sodium phosphate dibasic, sodium phosphate monobasic, water.
FreshKote
(Focus Laboratories)
15mL bottle Polyvinyl pyrrolidone2.0%, Polyvinyl alcohol 2.7% Boric acid, Disodium edetate dihydrate, Ethanol, Glycerin, Lecithin, Polixetonium, Polysorbate-80, Potassium chloride, Purified water, Sodium chloride
Retaine MGD
(Ocusoft)
(Equivalent to Cationorm which is sold in Europe)
30 PF vials (0.4 mL) Light Mineral Oil (0.5) Mineral Oil (0.5%)  Cetalkonium chloride, glycerol, poloxamer 188, tris hydrochloride, tromethamine, tyloxapol, water for injection.
Retaine HPMC
(Ocusoft)
10mL bottle
(preservative free)
Hypromellose 0.3% Citric acid, sodium citrate, sorbitol, water for injection.
Retaine CMC
(Ocusoft)
30 PF vials (0.6 mL) Carboxymethylcellulose sodium 0.5% Calcium chloride, magnesium chloride, potassium chloride, purified water, sodium chloride, sodium lactate. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Retaine PM
(Ocusoft)
5g tube Mineral oil (20%) White petrolatum (80%) none
TheraTears dry eye therapy
(Akorn)
30mL bottle Sodium Carboxymethyl Cellulose (0.25%) Borate Buffers, Calcium Chloride, Dequest, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Bicarbonate, Sodium Chloride, Sodium Perborate, Sodium Phosphate
32 PF vials (0.6 mL) Borate Buffers, Calcium Chloride, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Bicarbonate, Sodium Chloride and Sodium Phosphate.
TheraTears nighttime dry eye therapy (gel)
(Akorn)
28 PF vials (0.6 mL) Sodium Carboxymethyl Cellulose (1%) Borate Buffer, Calcium Chloride, Magnesium Chloride, Potassium Chloride, Water (Purified), Sodium Bicarbonate (Baking Soda), Sodium Chloride, Sodium Phosphate
Contact lens comfort drops
(Akorn)
15mL bottle Carmellose sodium Borate Buffer, Sodium Chloride, Potassium Chloride, Sodium Bicarbonate (baking soda), Calcium Chloride, Magnesium Chloride, Sodium Phosphate, Sodium Perborate stabilized with phosphonic acid
NanoTears TF
(Altaire)
15mL bottle
30mL bottle
Polyethylene Glycol 400 0.4%
Propylene Glycol 0.3%
Boric acid, castor oil, gellan gum, glycerin, hydroxyethylcellulose, polyoxyl 35 castor oil,polysorbate 80, sorbitol, tromethamine, Vanish (stabilized peroxy complex as a preservative) and purified water.
NanoTears TF PF
(Altaire)
32 0.6mL vials Polyethylene Glycol 400 0.4%
Propylene Glycol 0.3% 
Boric acid, gellan gum, glycerin, hydroxyethylcellulose, polyoxyl 35 castor oil, polysorbate 80, sorbitol, tromethamine, and purified water.
NanoTears XP
(Altaire)
10mL bottle Polyethylene Glycol 400 0.4%
Propylene Glycol 0.3%  
Boric acid,  castor oil, gellan gum, glycerin, hydroxyethylcellulose, polyoxyl 35 castor oil, polysorbate 80, sorbitol, tromethamine, Vanish (stabilized peroxy complex as a preservative) and purified water. Sodium hydroxide or hydrochloric acid may be added to adjust the pH.
Clear Eyes Pure Relief for Dry Eyes "240 drops" PF multi-dose bottle Glycerin 0.25% Boric acid, purified water, sodium borate, sodium chloride, sodium hyaluronate
Clear Eyes Outdoor Dry Eye Protection Bottle

Polyvinyl alcohol 0.5%

Povidone 0.6%

Benzalkonium Chloride, Dextose, Edetate Disodium, Potassium Chloride, Purified Water, Sodium Bicarbonate, Sodium Chloride, Sodium Citrate, Sodium Phosphate (mono- and dibasic)
Clear Eyes Natural Tears Lubricant Bottle

Polyvinyl alcohol 0.5%

Povidone 0.6%

Benzalkonium Chloride, Dextose, Edetate Disodium, Potassium Chloride, Purified Water, Sodium Bicarbonate, Sodium Chloride, Sodium Citrate, Sodium Phosphate (mono- and dibasic)
Clear Eyes Complete Symptom Relief Bottle

Hypromellose 0.20% (Lubricant)

Naphazoline HCl 0.025% (Redness Reliever)

Polysorbate 80 0.50% (Lubricant)

Zinc Sulfate 0.25% (Astringent)

Calcium Chloride, Citric Acid, Edetate Disodium, Magnesium Chloride, Potassium Chloride, Purified water, Sodium Citrate, Sodium Chloride, Sorbic Acid
Clear Eyes Triple Action Bottle

Polyvinyl Alcohol 0.5% (Lubricant)

Povidone 0.6% (Lubricant)

Tetrahydrozoline Hydrochloride 0.05% (Redness Reliever)

Benzalkonium Chloride, Dextrose, Dibasic Sodium Phosphate, Edetate Disodium, Monobasic Sodium Phosphate, Potassium Chloride, Purified Water, Sodium Bicarbonate, Sodium Chloride, Sodium Citrate
Clear Eyes Pure Relief Multi Symptom PF multi-dose bottle

Phenylephrine Hydrochloride 0.10% (Redness Reliever)

Glycerin 0.25% (Lubricant)

Hypromellose 0.30% (Lubricant)

Citric Acid, Purified Water, Sodium Chloride, Sodium Citrate
Visine Dry Eye Relief 15mL bottle

Glycerin 0.2%

Hypromellose 0.2%

Polyethylene glycol 400 1%

ascorbic acid, benzalkomium chloride, boric acid, dextrose, disodium phosphate, glycine, magnesium chloride, potassium chloride, purified water, sodium borate, sodium chloride, sodium citrate, sodium lactate
Visine Tired Eye Dry Eye Relief 15mL bottle

Glycerin 0.2%

Hypromellose 0.36%

Polyethylene glycol 400 1%

ascorbic acid, boric acid, dextrose, glycine, magnesium chloride, polyquaternium-42, potassium chloride, purified water, sodium borate, sodium chloride, sodium citrate, sodium lactate, sodium phosphate dibasic
Visine Totality Multi-Symptom Relief 15mL bottle

Glycerin 0.2%

Hypromellose 0.36%

Polyethylene glycol 400 1%

Tetrahydrozoline HCI 0.05%

Zinc sulfate 0.25%

benzalkonium chloride, boric acid, edetate disodium, purified water, sodium chloride, sodium citrate